Dr. Vincent Pascoli
Maître-Assistant / Ambizione Fellow
Phone : (0041) 22 379 54 37

After obtaining a first academic diploma of applied biology in 1996 (Clermont-Ferrand), I worked in the CNS pharmacology department of a pharmaceutical research center (Lafon Laboratory). During five years, I performed various behavioural experiments to detect potential therapeutic activities of original compounds. At the same time I also followed an academic course in life Science in the Conservatoire National des Arts et Métiers (Paris). In 2001, I moved to the Inserm Unit of Dr. Jean-Antoine Girault in Paris to pursue a Masters degree. During this year I discovered academic research with Dr. Emmanuel Valjent and published several different studies regarding the activation of proteins by phosphorylation in brain structures related to drugs of abuse. From 2002 to 2005, I returned to pharmaceutical research, where I was the head of a behavioural team. In particular, I explored the procognitive activity of histaminergic H3 antagonists. Following this period I started my PhD at the University Pierre et Marie Curie of Paris in the laboratory of Dr Jocelyne Caboche in 2006. During this time I conducted in vivo and in vitro experiments to further characterise the cellular and molecular events that, when triggered by dopamine and glutamate, converge to activate the extracellular signal-regulated kinase (ERK) pathway in striatal neurons and to regulate gene expression. These mechanisms are particularly important as activation of ERK in medium spiny neurons of the striatum has been shown to be crucial for long term behavioural alterations induced by drugs of abuse. I joined the Laboratory of Prof. Christian Lüscher in 2009 as a Post-doc, where I am interested in the role of the ERK pathway in synaptic plasticity within the striatum.

Publications :

  • Pascoli V 1, Terrier J 1, Espallergues J, Valjent E, O'Connor EC, Lüscher C. (2014). Contrasting forms of cocaine-evoked plasticity control components of relapse. Nature, 509(7501), 459–464. doi:10.1038/nature13257 1 Pascoli V and Terrier J contributed equally to the work

  • Nelson AB, Hang GB, Grueter BA, Pascoli V, Lüscher C, Malenka RC, Kreitzer AC. A comparison of striatal-dependant behaviors in wild-type and hemizygous Drd1a and Drd2 BAC transgenic mice. J Neurosci. 2012 Jul 4;32(27):9119-23.

  • Optogenetic reversal of cocaine-evoked synaptic potentiation normalizes behavioural sensitization. Lüscher C, Pascoli V. Med Sci (Paris). 2012 Apr;28(4):353-5. Epub 2012 Apr 25.

  • Vincent Pascoli, Marc Turiault, Christian Lüscher. Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour. Nature 2011, doi:10.1038/nature10709, Published online 07 December 2011.

  • Besnard A, Bouveyron N, Kappes V, Pascoli V, Pagès C, Heck N, Vanhoutte P, Caboche J. Alterations of molecular and behavioral responses to cocaine by selective inhibition of Elk-1 phosphorylation. J Neurosci. 2011 Oct 5;31(40):14296-307.

  • Pascoli V, Besnard A, Hervé D, Pagès C, Heck N, Girault JA, Caboche J, Vanhoutte P. Cyclic adenosine monophosphate-independent tyrosine phosphorylation of NR2B mediates cocaine-induced extracellular signal-regulated kinase activation. Biol Psychiatry. 2011 Feb 1;69(3):218-27. Epub 2010 Nov 4.

  • Pascoli V, Herve D, Pagès C, Heck N, Girault JA, Caboche J and Vanhoutte P. Cocaine-induced signaling in striatal neurons depends on the potentiation of NMDA receptors by dopamine D1 receptors. Mol Cell Neurosci. 2009 Jul;41(3):325-36. Epub 2009 May 3

  • Trifilieff P, Lavaur J, Pascoli V, Kappès V, Brami-Cherrier K, Pagès C, Micheau J, Caboche J, Vanhoutte P (2009) Endocytosis controls glutamate-induced nuclear accumulation of ERK. Mol Cell Neurosci. 41(3):325-36.

  • Pascoli V, Boer-Saccomani C, Hermant JF (2009) H3 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing retrieval. Psychopharmacology (Berl). 202(1-3):141-52.

  • Lavaur J, Bernard F, Trifilieff P, Pascoli V, Kappes V, Pagès C, Vanhoutte P, Caboche J (2007) A TAT-DEF-Elk-1 peptide regulates the cytonuclear trafficking of Elk-1 and controls cytoskeleton dynamics. J Neurosci. 27(52):14448-58

  • Corvol JC, Valjent E, Pascoli V, Robin A, Stipanovich A, Luedtke RR, Belluscio L, Girault JA, Hervé D (2007) Quantitative changes in Galphaolf protein levels, but not D1 receptor, alter specifically acute responses to psychostimulants. Neuropsychopharmacology 32(5):1109-21

  • Pascoli V, Valjent E, Corbillé AG, Corvol JC, Tassin JP, Girault JA, Hervé D (2005) cAMP and extracellular signal-regulated kinase signaling in response to d-amphetamine and methylphenidate in the prefrontal cortex in vivo: role of beta 1-adrenoceptors. Mol Pharmacol. 68(2):421-9

  • Valjent E, Pascoli V, Svenningsson P, Paul S, Enslen H, Corvol JC, Stipanovich A, Caboche J, Lombroso PJ, Nairn AC, Greengard P, Hervé D, Girault JA (2005) Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. PNAS 102(2):491-6

  • Ravary A, Muzerelle A, Hervé D, Pascoli V, Ba-Charvet KN, Girault JA, Welker E, Gaspar P (2003) Adenylate cyclase 1 as a key actor in the refinement of retinal projection maps. J Neurosci. 23(6):2228-38