I joined the Lüscher lab in December, 2012 after completing my PhD in pharmacology at the University of Toronto. My graduate work in Dr. José Nobrega’s lab at the Center for Addiction and Mental Health was aimed at determining mechanisms underlying the anti-dyskinetic effects of deep brain stimulation (DBS) applied to different basal ganglia nuclei. Currently, my goal is to determine if DBS can alter synaptic plasticity in mesolimbic reward circuitry and associated behaviour induced by exposure to drugs of abuse.

Publications :

• Creed, MC., Ntamati, NR, Chandra, R., Lobo, MK., Lüscher, C. Convergence of reinforcing and anhedonic cocaine effects in the ventral pallidum.  Neuron.  (In Press).

• Creed, MC., Kaufling, J., Fois, G., Jalbert, M., Yuan, TF., Lüscher, C., Georges, F., Bellone, C.  Cocaine exposure enhances the activity of VTA dopamine neurons via calcium impermeable NMDARs.  Journal of Neuroscience.  (In Press).​
  

• Lüscher, C., Pascoli, V., Creed, MC. Optogenetic dissection of neural circuitry: From synaptic causalities to blue prints for novel treatments of behavioral diseases. Current Opinion in Neurobiology. 2015 Dec;35:95-100.

• Creed MC, Pascoli V, Lüscher C (2015). Refining deep brain stimulation to emulate optogenetic treatment of synaptic pathology. Science. 347(6222):659-64

• Visanji NP, Sarvestani IK, Creed MC, Shoaei YS, Nobrega JN, Hamani C, Hazrati LN (2015). Deep brain stimulation of the subthalamic nucleus preferentially alters the translational profile of striatopallidal neurons in an animal model of Parkinson's disease. Front. Cell. Neurosci (In Press)

• Nona CN, Creed MC, Hamani C, Nobrega JN (2014). Effects of high-frequency stimulation of the nucleus accumbens on the development and expression of ethanol sensitization in mice. Behav Pharmacol (e-pub ahead of print).

• Creed MC, Ntamati NR, Tan KR (2014). VTA GABA neurons modulate specific learning behaviors through the control of dopamine and cholinergic systems. Front Behav Neurosci. 22(8). e collection.

• Wheeler AL, Creed MC, Voineskos AN, Nobrega JN (2014). Changes in brain functional connectivity after chronic haloperidol in rats: a network anaylsis. Int J Neuropsychopharmacol. 17(8):1129-38.

• Creed MC, Lüscher C (2013). Drug-evoked synaptic plasticity: beyond metaplasticity. Curr Opin Neurobiol. 23(4):553-8.

• Aleksandrova LR, Creed MC, Fletcher PJ, Lobo DS, Hamani C, Nobrega JN (2013). Deep Brain Stimulation of the Subthalamic Nucleus Increases Premature Responding in a Rat Gambling Task. Behav Brain Res. E-pub head of print.

• Creed MC, Nobrega JN (2012). The role of serotonin in the antidyskinetic effects of deep brain stimulation: Focus on antipsychotic-induced motor symptoms. Rev Neurosci. E-pub ahead of print.

• Creed MC,Nobrega JN (2012). Neurobiological basis of dyskinetic effects induced by antipsychotics: the contribution of animal models. Curr Med Chem. E-pub ahead of print.

• Creed MC, Hamani C and Nobrega JN (2012). Effects of repeated deep brain stimulation on depressive- and anxiety-like behavior in rats: Comparing entopeduncular and subthalamic nuclei. Brain Stimul. E-pub ahead of print.

• Creed MC, Hamani C, Bridgman A, Fletcher PJ and Nobrega JN (2012). Contribution of decreased serotonin release to the antidyskinetic effects of deep brain stimulation in a rodent model of tardive dyskinesia: comparison of the subthalamic and entopeduncular nuclei. J Neurosci.32(28):9574-81.

• Creed MC, Hamani C, Nobrega JN (2012). Early gene mapping after deep brain stimulation in a rat model of tardive dyskinesia: comparison with transient local inactivation. Eur Neuropsychopharmacol. 22(7):506-17.

• Creed MC, Hamani C, Nobrega JN (2011). Deep brain stimulation of the subthalamic or entopeduncular nucleus attenuates vacuous chewing movements in a rodent model of tardive dyskinesia. Eur Neuropsychopharmacol. 21(5):393-400.

• Creed MC, Oraha A, Nobrega JN (2011). Effects of 5-HT(2A) and 5-HT(2C) receptor antagonists on acute and chronic dyskinetic effects induced by haloperidol in rats. Behav Brain Res.219(2):273-9.

• Kessas M,Creed MC, Nobrega JN (2010). An examination of synaptic proteins following chronic haloperidol in a rat model of tardive dyskinesia. Psychology and Neuroscience, 3(2):299-237.

• Creed MC, Milgram NW (2010). Amyloid-modifying therapies for Alzheimer's disease: therapeutic progress and its implications. 32(3):365-84.

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