Faculté de médecine Faculté de médecine

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Christian LUSCHER

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Prof.Dr.méd. Christian Lüscher

Full Professor

Twitter:@luscherc
(0041) 22 379 54 44
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Curriculum vitae

  • 2009- Full Professor (sabbatical done in 2010)
  • 2003-2009 Associate Professor
  • 1999-2003 Career Development Grant of the Swiss NSF (SCORE A)
  • 1996-99 Postdoctoral fellow at UCSF (Lab of Roger Nicoll)
  • 1993-96 Residency in neurology
  • 1990-93 Graduate student at the University of Bern (Lab of Hans-Rudolf Lüscher)
  • 1983-89 Medical School in Lausanne and Bern

Selected publications

  • Claire L. Padgett, Arnaud L. Lalive, Kelly R. Tan, Miho Terunuma, Michaelanne B. Munoz, Menelas N. Pangalos, Jose Martinez-Hernandez, Masahiko Watanabe, Stephen J. Moss, Rafael Lujan, Christian Lüscher and Paul A. Slesinger. Methamphetamine-Evoked Depression of GABA(B) Receptor Signaling in GABA Neurons of the VTA. Neuron. 2012 Mar 8;73(5):978-89.

  • Vincent Pascoli, Marc Turiault, Christian Lüscher. Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour. Nature 2011, doi:10.1038/nature10709, Published online 07 December 2011.

  • Arnaud L. Lalive, Uwe Rudolph, Christian Lüscher, Kelly R. Tan. Is there a way to curb benzodiazepine addiction? Swiss Med Wkly. 2011 Oct 19;141:w13277.

  • Bellone C, Mameli M, Lüscher C. In utero exposure to cocaine delays postnatal synaptic maturation of glutamatergic transmission in the VTA. Nat Neurosci. 2011 Oct 2. doi: 10.1038/nn.2930. [Epub ahead of print]

  • Terrier J, Ort A, Yvon C, Saj A, Vuilleumier P, Lüscher C. Bi-directional effect of increasing doses of baclofen on reinforcement learning. Front Behav Neurosci. 2011;5:40. Epub 2011 Jul 22.

  • Brown MT, Korn C, Lüscher C. Mimicking synaptic effects of addictive drugs with selective dopamine neuron stimulation. Channels (Austin). 2011 Nov 1;5(6). [Epub ahead of print]

  • Tan KR, Rudolph U, Lüscher C. Hooked on benzodiazepines: GABAA receptor subtypes and addiction Trends Neurosci. 2011 Apr;34(4):188-97. Epub 2011 Feb 25. Review.

  • Christian Lüscher and Robert C. Malenka. Drug-Evoked Synaptic Plasticity in Addiction: From Molecular Changes to Circuit Remodeling. Neuron 69, February 24, 2011: 650 - 663.

  • Mameli M, Lüscher C. Synaptic plasticity and addiction: learning mechanisms gone awry. Neuropharmacology, Epub: Jan 28 2011.

  • Manuel Mameli, Camilla Bellone, Matthew T.C. Brown & Christian Lüscher. Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area. Nature Neuroscience, Advance Online Publication, 20 February 2011.

  • Matthew T.C. Brown, Camilla Bellone, Manuel Mameli, Gwenael Labouèbe, Christina Bocklisch, Bénédicte Balland, Lionel Dahan, Rafael Luján, Karl Deisseroth, Christian Lüscher. Drug-Driven AMPA Receptor Redistribution Mimicked by Selective Dopamine Neuron Stimulation. PLoS ONE, Epub 2010 December 31.

  • Parlato R, Cruz H, Otto C, Murtra P, Parkitna JR, Martin M, Bura SA, Begus-Nahrmann Y, Von Bohlen und Hallbach O, Maldonado R, Schültz G, Lüscher C. Effects of the cell type-specific ablation of the cAMP-responsive transcription factor in noradrenergic neurons on locus coeruleus firing and withdrawal behavior after chronic exposure to morphine. J Neurochem. 2010 Nov;115(3):563-7.

  • Rounak Nassirpour, Laia Bahima, Arnaud L. Lalive, Christian Lüscher, Rafael Lujan, Paul A. Slesinger. Morphine- and CaMKII-Dependent Enhancement of GIRK Channel Signaling in Hippocampal Neurons. Journal of Neuroscience, 2010 October 6, 30(40):13419 –13430.

  • Christina Boscklich, Kelly Tan, Chritian Lüscher. Warum Schlafmittel wie Valium süchtig machen. Neurophysiologie, Spectrum der Wissenschaft, Juni 2010.

  • Lüscher C, Slesinger P. Emerging concepts for GIRK channels in health and disease. Nat Rev Neurosci. 2010 May ; 11(5): 301–315.

  • Lüscher C, Huber K. Group 1 mGluR-dependent long-term depression (mGluR-LTD): mechanism and implications for circuitry and disease. Neuron. 2010 Feb 25;65(4):445-59.

  • Kelly R. Tan, Matthew Brown, Gwenaël Labouèbe, Cédric Yvon, Cyril Creton, Jean-Marc Fritschy, Uwe Rudolph & Christian Lüscher. Neural bases for addictive properties of benzodiazepines. Nature 463, 469-474. Epub 2010 Feb 11.

  • Lüscher C. Drugs of Abuse. In Katzung BG (Ed.) Basic and Clinical Pharmacology. Lange Medical Books/McGraw-Hill (New-York) 11th edition, 2009 and 10th edition, 2007.

  • B. Balland, C. Lüscher. L'addiction: lorsque l'emballement des mécanismes d'apprentissage conduit à la perte du libre arbitre. Addiction from learning to compulsion. Psychiatr. Sci. Hum. Neurosci. (2009) 7:35-42.

  •  Lüscher C.. Against addiction, light at the end of the tunnel? J Physiol. 2009 Aug 1;587(Pt 15):3757.

  • Mameli M, Halbout B, Creton C, Engbloom D, Rodriguez Parkitna J, Spanagel R, Lüscher C. Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Nat Neurosci. 2009 Aug;12(8):1036-41. Epub Jul 13.

  • Lüscher C, Isaac JT. The synapse; center stage for many brain diseases. J Physiol. 2009 Feb 15;587 (Pt 4):727-9. Epub 2008 Dec 15.

  • Lüscher C, Frerking M. NMDAR-LTD, mGluR-LTD. In Squirre, L.(Ed.) Encyclopedia of Neuroscience, 10500p Elsevier, ISBN 978-0-08-045046-9,2008.

  • Lomazzi M, Slesinger PA, Lüscher C.. Trends Pharmacol Sci. 2008 Nov;29(11):544-9. Epub 2008 Sep 12. Review.

  • Bellone C., Lüscher C., Mameli M.. Mechanisms of synaptic depression triggered by metabotropic glutamate receptors. Cell. Mol. Life Science 2008 Sep;65(18):2913-23. Review. 

  • Engblom D., Bilbao A., Sanchis-Segura C., Dahan L., Pereau-lenz S., Balland B., Parkitna J.R., Lujan R., Halbout B., Mameli M., Parlato R., Sprengel R., Lüscher C., Schütz G., Spanagel R.. Glutamate receptors on dopamine neurons control the persistence of cocaine-seeking. Neuron 2008 Aug 14; 59(3):497-508. 

  • Burkhard PR, Catalano-Chiuvé S, Gronchi-Perrin A, Berney A, Vingerhoets FJ, Lüscher C.. Impulse control disorders and Parkinson's disease. Rev Med Suisse. 2008 May 7;4(156):1145-8, 1150. French.

  • Lüscher C, Bellone C. Cocaine-evoked synaptic plasticity: a key to addiction? Nat Neurosci. 2008 Jul;11(7):737-8.

  • Cruz HG, Berton F, Sollini M, Blanchet C, Pravetoni M, Wickman K. & Lüscher C. Absence and rescue of morphine withdrawal in GIRK knockout mice, J Neurosci, 28:4069-77, 2008

  • Balland B, Lüscher C.. Addiction: the dark side of learning. Pediatr Res. 2008 Jan;63(1):1.

  • Ballan B, Lüscher C. L'addiction: une maladie de l'apprentissage et de la mémoire. Dépendances, 4: 18-19, 2007.

  • Labouèbe G, Lomazzi M, Cruz HG, Creton C, Luján R, Li M, Yanagawa Y, Obata K, Watanabe M, Wickman K, Boyer SB, Slesinger PA, Lüscher C. . RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area. Nature Neuroscience 2007 Dec;10(12):1559-68. Epub 2007 Oct 28.

  • Mameli M., Balland B., Lujan R., Lüscher C.. Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area. Science. 2007 July; 317(5837):530-3.

  • Roppolo D, Vollery S, Kan CD, Lüscher C, Broillet, MC, Rodriguez, I. Gene cluster lock after pheromone receptor gene choice, EMBO J. 25:3423-30, 2007

  • Lüscher C, ungless MA. the mechanistic classification of addictive drugs. PLoS Med. 2006 Nov;3(11):e437. Review.

  • Roppolo D, Ribaud V, Pauli Jungo V, Lüscher C. & Rodriguez, I. Projection of the Grüneberg ganglion to the mouse olfactory bulb, Eur J Neurosci, 23:2887-94, 2006

  • Bellone C. & Lüscher C. Cocaine triggered AMPA receptor redistribution is reversed in vivo by m-GluR-dependent long-term depression. Nat Neurosci. 2006 May;9(5):636-41. Epub 2006 April.

  • Cruz HG, Lüscher C.. Applications of two-photon microscopy in the neurosciences. Front Biosci. 2005 Sep 1 ;10:2263-78.

  • Bellone C, Lüscher C.. mGluRs induce a long-term depression in the ventral tegmental area that involves a switch of the subunit composition of AMPA receptors, Eur. J. Neurosci. 2005 Mar;21(5):1280-8.

  • Mutneja, M, Berton F, Suen KF, Lüscher C, Slesinger PA. Endogenous RGS proteins enhance acute desensitization of GABAB receptor-activated GIRK currents in HEK-293T cells. Euro. J. Physiol. 2005 Apr;450:(1):61-73. Epub 2004 Dec 10.

  • Bradaia, A.; Berton, F.; Ferrari, S. & Lüscher, C beta-arrestin2, interacting with phosphodiesterase 4, regulates synaptic release probability and presynaptic inhibition by opioids, PNAS. 2005 Feb 22;102(8):3034-39. Epub 2005 Feb 17.

  • Cruz, H. ; Ivanova, T. ; Lunn, M-L. ; Stoffel,M., Slesinger, P. ; and Lüscher, C. Bi-directional effects of GABAB receptor agonists on the mesolimbic dopamine system, Nat. Neurosci. 2004 Feb;7(2):153-9. Epub Jan 2004.

  • Blanchet, C.; Sollini, M. & Lüscher, C. Two distinct forms of desensitization of GIRK currents evoked by alkaloid and peptide µ-opioid receptor agonist, Mol Cell Neurosci. 2003 Oct;24(2):517-23.

  • Boschat C, Pélofi C, Randin O, Roppolo D, Lüscher C, Broillet MC, Rodriguez I.. Pheromone detection mediated by a V1r vomeronasal receptor. Nat. Neurosci. 2002 Dec;5(12):1261-2.

  • Blanchet, C. and Lüscher, C. Agonist induced desensitization of µ-opioid receptors: initiation at the receptor, expression at the effector. PNAS 2002 Apr 2;99(7):4674-9Epub 2002 Mar 26.

  • Lüscher C, Frerking M.. Restless AMPA receptors: implications for synaptic transmission and plasticity. Trends Neurosci. 2001 Nov;24(11):665-70.

  • Schuler V, Lüscher C, Blanchet C, Klix N, Sansig G, Klebs K, Schmutz M, Heid J, Gentry C, Urban L, Fox A, Spooren W, Jaton AL, Vigouret J, Pozza M, Kelly PH, Mosbacher J, Froesti W, Ksslin , Korn R, Bischoff S, Kaupmann K, Van Der Putten H, Bettler B.. Epilepsy, Hyperagesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)). Neuron 2001 jul 19;31(1):47-58.

  • Lüscher C, Nicoll RC, Malenka RC, Muller D.. Synaptic plasticity and dynamic modulation of the postsynaptic membrane. Nat. Neurosci. 2000 Jun;3(6):545-50. Review.

  • Lüscher C, Xia H, Beattie EC, Carroll RC, Von Zastrow M, Malenka RC, Nicoll RA.. Neuron 1999 Nov;24(3):649-58.

  • Carroll RC, Beattie EC, Xia H, Lüscher C, Altschuler Y, Nicoll RA, Malenka RC, Von Zastrow M.. Dynamin-dependent endocytosis of ionotropic glutamate receptors. PNAS 1999 Nov 23;96(24):14112-7.

  • Lüscher C, Malenka RC, Nicoll RA.. Monitoring glutamate release during LTP with glial transporter currents. Neuron 1998 aug;21(2):435-41.

  • Lüscher C, Jan LY, Stoffel M, Malenka RC, Nicoll RA.. G protein-coupled inwardly rectifzing K+ channels (GIRKs) mrdiate postsynaptic but not presynaptic transmitter actions in hippocampal neurons. Neuron 1997 sept;19(3):687-95. Erratum in Neuron 1997 Oct;19(4):following 945.

  • Lüscher C, Rösler KM, Mathis J, Beer S, Hess CW. The perception of movement elicited by magnetic cortex stimulation depends on the site of stimulation. Exp Brain Res. 1996 Apr;109(1):154-7.

  • Lipp P, Lüscher C, Niggli E. Flash photolysis of DM-nitrophen and diazo-2 in cardiac myocytes characterized by confocal microscopy. Cell Calcium. 1996 Mar;19(3):255-66.

  • Lüscher C, Lipp P, Lüscher HR, Niggli E. Control of action potential propagation by intracellular Ca in cultured dorsal root ganglion cells. J Physiol. 1996 Jan 15;490 ( Pt 2):319-24.

  • Lüscher C, Clamann HP, Lüscher HR. Practical guidance for testing the accurancy of deconvolution results from quantal analysis. Pflugers Arch. 1994 Oct;428(3-4):418-21.

  • Lüscher C, Streit J, Quadroni R, Lüscher HR. Action potential propagation through embryonic dorsal root ganglion cells in culture. II Decrease of conduction reliability during repetitive stimulation. J Neurophysiol. 1994 Aug;72(2):634-43.

  • Lüscher C, Streit J, Quadroni R, Lüscher HR. Action potential propagation through embryonic dorsal root ganglion cells in culture. I Influence of the cell morphology on propagation properties. J Neurophysiol. 1994 Aug;72(2):622-33.

  • Lüscher C, Frei P, de Limoges D. Modification of a consumer audio tape (DAT) for analog data recording. J Neurosci Methods. 1992 Dec;45(3):155-8.

  • Streit J, Lüscher C, Lüscher HR. Depression of synaptic potentials by high frequency stimulation in embryonic motoneurons grown in spinal cord slice culture. J Neurophysiol. 1992 Nov;68(5):1793-803.

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